PhD, Cornell University, 1979
BS, Knox College, 1973
Harold Lamport Award for Biophysics and Physiology, New York Academy of Sciences
National Science Foundation Women in Science and Engineering Faculty Award
John Simon Guggenheim Memorial Foundation Fellow

Michael I. Kotlikoff, V.M.D., Ph.D.
Horace White Professor of Chemistry and Chemical Biology

Barbara A. Baird

Phone

607-253-3336

Address

Department of Biomedical Sciences College of Veterinary Medicine
T4-018 Veterinary Research Tower
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Lab Web Site
Department Profile

Background 1973 B.A., University of Pennsylvania, Philadelphia, Literature
1981 V.M.D., University of Pennsylvania, Philadelphia, Veterinary Medicine
1984 Ph.D., University of California, Davis, Physiology

Research Description

My laboratory focuses on the molecular processes underlying cardiovascular development, function, and dysfunction. We are currently working on two general areas: the study of repair processes within the damaged heart, including the role of cardiovascular and vascular progenitors and cell-based therapies. In a second project we develop genetic sensors and BAC transgenic for in vivo molecular physiology. We use mouse genetics extensively and have developed numerous lines that facilitate the analysis of developmental, regulatory, and regenerative processes in vivo. A major focus of the laboratory is post-infarction cardiac repair and the lineage potential of cardiac and vascular precursors.

Recent Publications

  1. Xin, H-B, T Senbonmatsu, D Cheng, Y-X Wang, J Copello, G Ji, ML Collier, K-Y Deng, LH Jeyakumar, MA Magnuson, T Inagami, MI Kotlikoff, and S Fleischer. Estrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature, 416:334-337, 2002.
  2. Tallini, NY, M Ohkura, B-R Choi, G Ji, K Imoto, R Doran, J Lee, P Plan, J Wilson, H-B Xin, A Sanbe, J Gulick, J Robbins, G Salama, J Nakai, and MI Kotlikoff. Imaging Cellular Signals in the Heart in Vivo: Cardiac expression of the high signal Ca2+ indicator GCaMP2. Proc Natl Acad Sci 103:4753-4758, 2006.
  3. Tallini, YN, JF Brekke, B Shui, R Doran, SM Hwang, J Nakai, G Salama, S Segal, MI Kotlikoff. Propagated endothelial Ca2+ waves and arterioloar dilation in vivo: measurements in Cx40BAC-GCaMP2 transgenic mice. Circ Research 101:1300-1309, 2007.
  4. Roell, W, T Lewalter, B-R Choi, B-R, YN Tallini, T Bostani, U Becher, P Sasse, S-M Hwang, R Doran, M Breitbach, S Reining, B Gabris, A Welz, G Salama, JW Schrickel, MI Kotlikoff, BK Fleischmann. Engraftment of electrically coupled cells in the heart prevents post-infarct ventricular arrhythmias. Nature 450:819-824, 2007.
  5. Ledoux, J, MS Taylor, AD Bonev, RM Hannah, V Solodushko, B Shui, YN Tallini, MI Kotlikoff, MT Nelson. Functional architecture of IP3 signaling in restricted spaces of myoendothelial projections. Proc Natl Acad Sci 105:9627-32, 2008.
  6. Wang, Q, B Shui, MI Kotlikoff, H Sondermann. Structural basis for calcium sensing by GCaMP2. Structure 16:1817-1827, 2008.
  7. Tallini, Y, KS Greene, M Craven, A Spealman, M Hesse, J Smith, A Woods, B Singh, A Yen, B Fleischman, and MI Kotlikoff. c-kit+ precursors in the neonatal heart specify all cardiac lineages. Proc Natl Acad Sci 106:1808-13, 2009.
  8. Shui, B, A Ozer, W Zipfel, N Sahu, A Singh, J Lis, H Shi, MI Kotlikoff. RNA Aptamers that Functionally Interact with Green Fluorescent Protein and Its Derivatives. Nucleic Acids Res 40:e39, 2012.
  9. Sonkusare, SK, AD Bonev, J Ledoux, MI Kotlikoff, DC Hill-Eubanks, MT Nelson. Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science 336:597-601, 2012.
  10. Shiba, Y, S Fernandes, W-Z Zhu, D Filice, V Muskheli, J Kim, NJ Palpant, J Gantz, KW Moyes, H Reinecke, BV Biber, T Dardas, JL Mignone, A Izawa, R Hanna, M Viswanathan, JD Gold, MI Kotlikoff, N Sarvazyan, MW Kay, CE Murry, and MA Laflamme. Human ESC-derived cardiomyocytes electrically integrate and suppress arrhythmias in injured hearts. Nature 489:322-325, 2012.
  11. Jesty, SA, MA Steffey, FK Lee, M Breitbach, M Hesse, S Reining, JC Lee, RM Doran, AY Nikitin, BK Fleischmann, and MI Kotlikoff. Cardiovascular precursors support postinfarction myogenesis in the neonatal, but not the adult, heart. Proc Natl Acad Sci. USA 109:13380-13385, 2012.
  12. Shui B, A Ozer, W Zipfel, N Sahu, A Singh, JT Lis, H Shi, MI Kotlikoff. RNA aptamers that functionally interact with green fluorescent proetin and its derivatives. Nucleic Acids Res 40:e39, 2012.
  13. Hesse, M, A Raulf, G Pilz, C Haberlandt, AM Klein, R Jabs, H Zaehres, CJ Fugemann, K Zimmermann, J Trebicka, A Welz, A Pfeifer, W Roll, MI Kotlikoff C Steinhauser, M Gotz, HR Scholer, and BK Fleischmann. Direct visualization of cell division using high resolution imaging of M-phase of the cell cycle. Nature Communications 3:1076, 2012.
  14. Nadworny, AS, MR Guruju, D Poor, RM Doran, RV Sharma, MI Kotlikoff, and RL Davisson. Nox2 and Nox4 influence c-kit+ cardiac precursor cell status and differentiation. Am J Physiol Heart Circ Physiol 305:H829-42, 2013.
  15. Tallini, YN, KS Greene, B Shui, CW Russell, JC Lee, RM Doran, J Nakai, MI Kotlikoff. Genetically encoded probes provide a window on embryonic arrhythmia. Methods Mol Biol. 1092:195-219, 2014.
  16. Kotlikoff, MI. BACs to the future: new genetic models for cardiovascular discovery. Cardiovasc Res. 101(1):7-8, 2014.
  17. Hesse, M, BK Fleischmann, and MI Kotlikoff. The Role of C-kit Expressing Cells in Heart Repair. Stem Cells (In press).